Biomolecular mechanisms of staphylococcal biofilm formation.

نویسندگان

  • Garry Laverty
  • Sean P Gorman
  • Brendan F Gilmore
چکیده

The multitude of biomolecular and regulatory factors involved in staphylococcal adhesion and biofilm formation owe much to their ability to colonize surfaces, allowing the biofilm form to become the preferential bacterial phenotype. Judging by total number, biomass and variety of environments colonized, bacteria can be categorized as the most successful lifeform on earth. This is due to the ability of bacteria and other microorganisms to respond phenotypically via biomolecular processes to the stresses of their surrounding environment. This review focuses on the specific pathways involved in the adhesion of the Gram-positive bacteria Staphylococcus epidermidis and Staphylococcus aureus with reference to the role of specific cell surface adhesins, the ica operon, accumulation-associated proteins and quorum-sensing systems and their significance in medical device-related infection.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

بررسی برخی از مواد آنتی سپتیک بر بیوفیلم سویه های استافیلوکوکی جدا شده از پوست بیماران بستری در بخش عفونی

Background: Excessive use of antibiotics and biocides has led to emergence of resistant Staphylococcal strains.  The aim of this study was to examine resistance of Staphylococcal strains biofilm isolated to biocidal components. Methods: 100 clinical isolates of Staphylococcus aureus were collected from hospitalized patients with infectious skins from two Shohadaye Tajrish and Valiasr ho...

متن کامل

Detection of icaABCD Genes and Biofilm Formation in Clinical Isolates of Methicillin Resistant Staphylococcus aureus

Background & Objectives:  Methicillin resistance Staphylococcus aureus (MRSA) is one of the most important pathogens that causes several nosocomial and community infections. Adhesion to surfaces and biofilm formation is considered main step in staphylococcal infection. The aims of this study were to determine presence oficaABCD genes and relation to the biofilm formation in of...

متن کامل

Molecular and Phenotypic Characteristics of Staphylococcus Hominis Isolates From Pediatric Infections

Background: Staphylococcus hominis has been recently emerged as an opportunistic hospital-associated pathogen. The aim of this study was to characterize the antimicrobial susceptibility pattern, biofilm formation, and staphylococcal cassette chromosome mec (SCCmec) types among clinical isolates of S. hominis obtained from pediatric infections. Methods: Totall...

متن کامل

Dose-Dependent Effects of Common Antibiotics Used to Treat Staphylococcus aureus on Biofilm Formation

Background & Objective: Staphylococcus aureus, especially methicillin-resistant S. aureus (MRSA), represent serious nosocomial and community infections. Biofilm formation as an important virulence factor may be affected by sub-inhibitory levels of antibiotics. Few studies examined the effects of all therapeutic antimicrobial agents on...

متن کامل

Investigation of the effect of biosurfactant of Bacillus subtilis against Staphylococcus strains biofilms

Background: Biosurfactants are compounds that are produced by different microorganisms and have an emulsifying property. This study aimed to investigate extractive biosurfactant from bacillus subtilis (PTCC1720) against the biofilms of Staphylococcus aureus (PTCC 1112), Staphylococcus saprophyticus (PTCC 1440) and Staphylococcus epidermidis (PTCC 1435). Materials and Methods: This study was con...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Future microbiology

دوره 8 4  شماره 

صفحات  -

تاریخ انتشار 2013